p53 promotes alveolar epithelial differentiation of rat bone marrow-derived mesenchymal stem cells <i>in vitro</i>

Bone marrow-derived mesenchymal stem cells (BMSCs) have been extensively studied for potential clinical use. Recently, increasing attention is being paid to the relationship between p53 and BMSCs differentiation. In this study, we investigated effects of on alveolar epithelial differentiation BMSCs. Rat (rBMSCs) were cultured with without hyperoxia-damaged lung tissue observe their process in vitro. Furthermore, expression was inhibited by pifithrin-α during rBMSCs Transmission electron microscopy, immunofluorescence, luciferase assay, an analysis cell proliferation apoptosis levels performed examine changes rBMSCs. We found that vitro exhibited when co-cultured damaged tissue, apoptosis, proliferation, significantly altered process. (a specific inhibitor), alleviated, promoted, blocked. Our results suggest can effectively regulate These provide basis developing more effective cellular therapies diseases further research.